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J Oncol Pharm Pract. 2005 Dec;11(4):155-7.

Leaching of diethylhexyl phthalate from polyvinyl chloride materials into etoposide intravenous solutions.

Author information

1
British Columbia Cancer Agency, Vancouver, BC, V5Z 4E6, Canada. mdelemos@bccancer.bc.ca

Abstract

Etoposide intravenous solution is associated with leaching of diethylhexyl phthalate (DEHP) from bags and tubings made from polyvinyl chloride (PVC). Recent evidence suggests that this may be more substantial than previously found. Since DEHP is potentially hepatotoxic and carcinogenic, it is preferable to prepare and administer etoposide bags and tubings made from non-PVC materials.

PMID:
16595068
DOI:
10.1191/1078155205jp164oa
[Indexed for MEDLINE]

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