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Dev Genes Evol. 2006 Oct;216(10):635-9. Epub 2006 Apr 4.

The chemokine SDF-1 regulates blastema formation during zebrafish fin regeneration.

Author information

1
UFR de Biologie, Université Paris 7-Denis Diderot, 2 pl. Jussieu, 75005, Paris, France.

Abstract

The work presented in this study focuses on blastema formation in epimorphic regeneration. We describe the expression pattern of Sdf1a and Sdf1b (the chemokines stromal-cell-derived factor-1a and 1b) and their two receptors Cxcr4a and Cxcr4b during zebrafish fin regeneration. We demonstrate that Sdf1a/Cxcr4a plays a critical role in fin regeneration and more precisely in epidermal cell proliferation, an important process for blastema formation. In mammals, a single cxcr4 gene is involved both in chemotaxis and cell proliferation and survival; we discuss in this study a possible functional division of the two cxcr4 zebrafish genes.

PMID:
16586100
DOI:
10.1007/s00427-006-0066-7
[Indexed for MEDLINE]

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