Abstract
Objective:
This study was carried out to confirm prior evidence of an effect of a single nucleotide polymorphism (SNP) in the metabotropic glutamate receptor 3 (GRM3) gene (a putative risk factor for schizophrenia) on measures of N-acetylaspartate in healthy comparison subjects.
Method:
Fifty-four carefully screened healthy volunteers genotyped at SNP rs6465084 underwent magnetic resonance spectroscopic imaging (MRSI) at 3 T and selected neuropsychological testing.
Results:
The A/A genotype group exhibited a significant reduction of N-acetylaspartate/creatine levels in the right dorsolateral prefrontal cortex compared to the G carriers. A tendency in the same direction was seen in the left dorsolateral prefrontal cortex and in the white matter adjacent to the prefrontal cortex.
Conclusions:
These findings provide further evidence that GRM3 affects prefrontal function and that variation in GRM3, monitored by SNP rs6465084, affects GRM3 function.
Publication types
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Comparative Study
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Research Support, N.I.H., Intramural
MeSH terms
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Aspartic Acid / analogs & derivatives*
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Aspartic Acid / analysis
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Aspartic Acid / metabolism
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Creatine / analysis
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Female
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Functional Laterality / physiology
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Genetic Predisposition to Disease
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Genotype*
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Heterozygote
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Humans
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Introns / genetics
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Introns / physiology
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Magnetic Resonance Spectroscopy
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Male
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Neuropsychological Tests
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Polymorphism, Single Nucleotide / genetics*
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Polymorphism, Single Nucleotide / physiology
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Prefrontal Cortex / chemistry*
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Prefrontal Cortex / metabolism
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Prefrontal Cortex / physiopathology
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Psychiatric Status Rating Scales / statistics & numerical data
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Receptors, Metabotropic Glutamate / genetics*
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Receptors, Metabotropic Glutamate / metabolism
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Receptors, Metabotropic Glutamate / physiology
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Schizophrenia / diagnosis
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Schizophrenia / genetics
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Schizophrenia / physiopathology
Substances
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Receptors, Metabotropic Glutamate
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metabotropic glutamate receptor 3
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Aspartic Acid
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N-acetylaspartate
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Creatine