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Trends Biochem Sci. 2006 May;31(5):247-50. Epub 2006 Apr 11.

Assembling the bacterial segrosome.

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1
Faculty of Life Sciences and Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7ND, UK. finbarr.hayes@manchester.ac.uk

Abstract

Genome segregation in prokaryotes is a highly ordered process that integrates with DNA replication, cytokinesis and other fundamental facets of the bacterial cell cycle. The segrosome is the nucleoprotein complex that mediates DNA segregation in bacteria, its assembly and organization is best understood for plasmid partition. The recent elucidation of structures of the ParB plasmid segregation protein bound to centromeric DNA, and of the tertiary structures of other segregation proteins, are key milestones in the path to deciphering the molecular basis of bacterial DNA segregation.

PMID:
16584885
DOI:
10.1016/j.tibs.2006.03.002
[Indexed for MEDLINE]
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