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Int J Oral Maxillofac Surg. 2006 Jun;35(6):551-5. Epub 2006 Apr 11.

Alveolar cleft osteoplasty using tissue-engineered osteogenic material.

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Center for Genetic and Regenerative Medicine, Nagoya University School of Medicine, Nagoya, Japan.


The use of tissue-engineered osteogenic material comprising platelet-rich plasma and autologous mesenchymal stem cells isolated, expanded and induced to osteogenic potential in bone augmentation procedures as a replacement for autologous bone grafts, offers predictable results with minimal donor-site morbidity. This material was applied for an alveolar cleft osteoplasty of a 9-year-old female patient. Serial computed tomograms showed the regenerated bone extending from the cleft walls after 3 months and bridging the cleft after 6 months, with 79.1% of the grafted region after 9 months at the time when the canine and lateral incisor in the affected side erupted in the reconstructed alveolar ridge.

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