Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Pharmacol Sci. 2006 May;27(5):244-50. Epub 2006 Apr 3.

Corticosteroid effects in the brain: U-shape it.

Author information

1
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands. joels@science.uva.nl

Abstract

The existence of U-shaped dose dependencies has been known for a long time. With regard to corticosteroid action in brain cells, a dual receptor system that works in opposing directions can explain the occurrence of a U-shaped dose dependency. However, recent evidence indicates that many cell- and tissue-specific factors (e.g. the local availability of corticosterone, the expression of receptor variants and the cellular content of other proteins and molecules) also determine the effectiveness of the hormone. This could result in dose dependencies with a different shape, despite the local presence of two receptor types.

PMID:
16584791
DOI:
10.1016/j.tips.2006.03.007
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center