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Nat Rev Microbiol. 2006 May;4(5):371-82.

Parallels among positive-strand RNA viruses, reverse-transcribing viruses and double-stranded RNA viruses.

Author information

1
Institute for Molecular Virology and Howard Hughes Medical Institute, University of Wisconsin--Madison, Madison, Wisconsin 53706, USA. ahlquist@wisc.edu

Abstract

Viruses are divided into seven classes on the basis of differing strategies for storing and replicating their genomes through RNA and/or DNA intermediates. Despite major differences among these classes, recent results reveal that the non-virion, intracellular RNA-replication complexes of some positive-strand RNA viruses share parallels with the structure, assembly and function of the replicative cores of extracellular virions of reverse-transcribing viruses and double-stranded RNA viruses. Therefore, at least four of seven principal virus classes share several underlying features in genome replication and might have emerged from common ancestors. This has implications for virus function, evolution and control.

PMID:
16582931
DOI:
10.1038/nrmicro1389
[Indexed for MEDLINE]

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