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Nat Immunol. 2006 May;7(5):482-8. Epub 2006 Apr 2.

CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium.

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1
Program in Immunology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.

Erratum in

  • Nat Immunol. 2006 Jun;7(6):672.

Abstract

Prevailing knowledge dictates that naive alphabeta T cells require activation in lymphoid tissues before differentiating into effector or memory T cells capable of trafficking to nonlymphoid tissues. Here we demonstrate that CD8(+) recent thymic emigrants (RTEs) migrated directly into the small intestine. CCR9, CCL25 and alpha(4)beta(7) integrin were required for gut entry of CD8(+) RTEs. After T cell receptor stimulation, intestinal CD8(+) RTEs proliferated and acquired a surface phenotype resembling that of intraepithelial lymphocytes. CD8(+) RTEs efficiently populated the gut of lymphotoxin-alpha-deficient mice, which lack lymphoid organs. These studies challenge the present understanding of naive alphabeta T cell trafficking and suggest that RTEs may be involved in maintaining a diverse immune repertoire at mucosal surfaces.

PMID:
16582913
DOI:
10.1038/ni1319
[Indexed for MEDLINE]
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