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Nat Immunol. 2006 May;7(5):489-97. Epub 2006 Apr 2.

A unique function for cyclin D3 in early B cell development.

Author information

1
Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois 60637, USA.

Abstract

During hematopoiesis, stem cell proliferation is dependent on expression of the D-type cyclins. However, little is known about how each cyclin D contributes to the development of specific hematopoietic lineages. Here, analysis of Ccnd1(-/-), Ccnd2(-/-), Ccnd3(-/-) and Ccnd2(-/-)Ccnd3(-/-) mice showed that cyclin D3 was uniquely required for the development of pre-B cells. Transcription of Ccnd3 was dependent on expression of the common gamma-chain. In contrast, expression of the pre-B cell receptor and activation of 'downstream' signaling pathways prevented proteasome-mediated degradation of cyclin D3. Cyclin D3 has a key function in B cell development by integrating cytokine and pre-B cell receptor-dependent signals to expand the pool of pre-B cells that have successfully rearranged immunoglobulin heavy chain.

PMID:
16582912
DOI:
10.1038/ni1324
[Indexed for MEDLINE]

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