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Nat Neurosci. 2006 May;9(5):602-4. Epub 2006 Apr 2.

Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation.

Author information

1
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, UK.

Abstract

Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs approximately 25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.

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PMID:
16582904
DOI:
10.1038/nn1678
[Indexed for MEDLINE]

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