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Cell Cycle. 2006 Mar;5(6):606-9. Epub 2006 Mar 15.

Cyclin e overexpression reduces infiltrative growth in breast cancer: yet another link between proliferation control and tumor invasion.

Author information

1
Pathology, Department of Laboratory Medicine, Lund University, Malmö University Hospital, Malmö, Sweden.

Abstract

Overexpression of cyclin E is strongly linked to an aggressive phenotype and poor prognosis in breast cancer. Unexpectedly, it has been shown that cyclin E overexpression decreases mobility and invasiveness of breast cancer cells. In fact, in a study of 985 breast cancers, cyclin E correlated with less infiltrative growth. This suggests a novel function for cyclin E in breast cancer tumorigenesis and a mutual control of proliferation and invasive behavior.

PMID:
16582601
DOI:
10.4161/cc.5.6.2569
[Indexed for MEDLINE]

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