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Neurochem Int. 2006 Sep;49(4):401-6. Epub 2006 Apr 3.

Rat brain proteome in morphine dependence.

Author information

1
Faculty of Chemistry and Regional Laboratory, Jagiellonian University, Krakow, Poland.

Abstract

The aim of this study was to reveal potential markers associated with drug dependence, using the proteomic approach. Gels containing samples derived from morphine-treated and control animals were compared and analyzed. Inspection of protein profiles, following TCA/acetone precipitation and the use of nano-scale liquid chromatography coupled to tandem mass spectrometry, allowed for identification of eleven potential dependence markers, mainly cytoplasmic and mitochondrial enzymes, e.g. proteins that belong to GTPase and GST superfamilies, ATPase, asparaginase or proteasome subunit p27 families.

PMID:
16581157
DOI:
10.1016/j.neuint.2006.01.024
[Indexed for MEDLINE]

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