Similarity in drugs: reflections on analogue design

Drug Discov Today. 2006 Apr;11(7-8):348-54. doi: 10.1016/j.drudis.2006.02.006.

Abstract

A survey of novel small-molecule therapeutics reveals that the majority of them result from analogue design and that their market value represents two-thirds of all small-molecule sales. In natural science, the term analogue, derived from the Latin and Greek analogia, has always been used to describe structural and functional similarity. Extended to drugs, this definition implies that the analogue of an existing drug molecule shares structural and pharmacological similarities with the original compound. Formally, this definition allows the establishment of three categories of drug analogues: analogues possessing chemical and pharmacological similarities (direct analogues); analogues possessing structural similarities only (structural analogues); and chemically different compounds displaying similar pharmacological properties (functional analogues).

Publication types

  • Review

MeSH terms

  • Animals
  • Antidepressive Agents / chemistry
  • Antidepressive Agents / pharmacology
  • Celecoxib
  • Cholinergic Antagonists / chemistry
  • Cholinergic Antagonists / pharmacology
  • Computer-Aided Design
  • Cyclooxygenase Inhibitors / chemistry
  • Cyclooxygenase Inhibitors / pharmacology
  • Cyproheptadine / analogs & derivatives
  • Cyproheptadine / chemistry
  • Cyproheptadine / pharmacology
  • Drug Design*
  • Drug Evaluation, Preclinical
  • GABA Antagonists / chemistry
  • GABA Antagonists / pharmacology
  • Humans
  • Molecular Structure
  • Pharmaceutical Preparations / chemistry*
  • Pyrazoles / chemistry
  • Pyrazoles / pharmacology
  • Stereoisomerism
  • Structure-Activity Relationship
  • Sulfonamides / chemistry
  • Sulfonamides / pharmacology

Substances

  • Antidepressive Agents
  • Cholinergic Antagonists
  • Cyclooxygenase Inhibitors
  • GABA Antagonists
  • Pharmaceutical Preparations
  • Pyrazoles
  • Sulfonamides
  • Cyproheptadine
  • 3-methoxycyproheptadine
  • Celecoxib