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Bioorg Med Chem Lett. 2006 Jun 1;16(11):2905-8. Epub 2006 Mar 31.

2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists.

Author information

1
Department of Medical Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. vince_colandrea@merck.com

Abstract

A series of 2,5-cis-disubstituted pyrrolidines were synthesized and evaluated as S1P receptor agonists. Compounds 15-21 were identified with good selectivity over S1P3 which lowered circulating lymphocytes after oral administration in mice.

PMID:
16580205
DOI:
10.1016/j.bmcl.2006.03.038
[Indexed for MEDLINE]

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