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Curr Allergy Asthma Rep. 2006 May;6(3):241-6.

Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population.

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Department of Human Genetics, The University of Chicago, 920 E. 58th Street, Chicago, IL 60637, USA.


Identifying genes that influence susceptibility to asthma-related and atopy-related phenotypes has been challenging, owing to clinical heterogeneity and a complex underlying genetic architecture that includes both gene-gene and gene-environment interactions. In this article, we report the results of genome-wide linkage and association studies of eight asthma-associated quantitative traits in the Hutterites, a founder population of European descent. Our study revealed significant sex-specific genetic architecture for at least five of these traits, and identified 13 genome-wide significant quantitative trait loci (QTL) by linkage or association that are present in only one of the sexes (nine in males, four in females).

[Indexed for MEDLINE]

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