Format

Send to

Choose Destination
See comment in PubMed Commons below
BJOG. 2006 May;113(5):544-51. Epub 2006 Mar 27.

Pregnancy-induced hypertension is associated with lower infant mortality in preterm singletons.

Author information

1
OMNI Research Group, Department of Obstetrics & Gynecology, University of Ottawa, Ottawa, Ontario, Canada.

Abstract

OBJECTIVE:

To assess the association between pregnancy-induced hypertension (PIH) and infant mortality.

DESIGN:

Retrospective cohort study.

SETTING:

Birth and infant death registration dataset of the USA.

POPULATION:

A total of 17,432,987 eligible, liveborn singleton births in 1995-2000.

METHODS:

Multivariate logistic regression was applied to evaluate the association between PIH and infant mortality, with adjustment of potential confounders.

MAIN OUTCOME MEASURES:

Infant death (0-364 days) and its three components: early neonatal death (0-6 days), late neonatal death (7-27 days), and postneonatal death (28-364 days).

RESULTS:

There was a significant reduction in infant mortality associated with PIH in early preterm infants (OR = 0.59, 95% CI: 0.56-0.63) and in late preterm infants (OR = 0.80, 95% CI: 0.73-0.87), but a significant increase in term infants (OR = 1.08, 95% CI: 1.02-1.14). Both in early preterm and late preterm births, early neonatal mortality (OR = 0.38, 95% CI: 0.34-0.42; OR = 0.68, 95% CI: 0.61-0.77) and late neonatal mortality (OR = 0.59, 95% CI: 0.50-0.70; OR = 0.76, 95% CI: 0.61-0.96) were decreased in infants born to mothers with PIH compared with those born to mothers with normal blood pressure. The PIH-associated reduction in neonatal mortality among preterm singletons was stronger in small-for-gestational-age infants than in normal growth infants and stronger in infants born to nulliparous women than in those born to multiparous women.

CONCLUSIONS:

PIH is associated with lower risk of infant death in preterm births but higher risk in term births.

[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center