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Neoplasma. 2006;53(2):92-6.

Surfing on prothymosin alpha proliferation and anti-apoptotic properties.

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  • 1Second Department of Cardiology, Evangelismos General Hospital of Athens, 10676 Athens, Greece.


Prothymosin alpha is an extremely abundant nuclear oncoprotein-transcription factor essential for cell cycle progression and proliferation that has been recently suggested as an anti- apoptotic factor. Similarly to other oncoproteins, prothymosin alpha is overexpressed in a variety of cancer tissues and cell lines. The present review highlights on the proliferation and anti-apoptotic properties of prothymosin alpha and its possible role in cancer development.

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