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Pediatr Crit Care Med. 2006 May;7(3):249-51.

Dopamine infusion: a possible cause of undiagnosed congenital hypothyroidism in preterm infants.

Author information

1
Neonatal Intensive Care Unit, Department of Critical Care Medicine, University Careggi Hospital, Florence, Italy.

Abstract

OBJECTIVE:

To describe the possibility that dopamine infusion can prevent early diagnosis of congenital hypothyroidism.

DESIGN:

Case report.

SETTING:

Medical neonatal intensive care unit of a tertiary academic medical center.

PATIENTS:

We report four preterm newborns affected by transient primary congenital hypothyroidism who showed low serum thyroxine and normal thyroid-stimulating hormone concentrations on primary screening performed during treatment with dopamine.

INTERVENTIONS:

Thyroid reevaluation screening after dopamine discontinuation.

MEASUREMENTS AND MAIN RESULTS:

Thyroid reevaluation showed elevated thyroid-stimulating hormone levels.

CONCLUSION:

We emphasize that dopamine capacity to suppress thyroid-stimulating hormone could prevent early diagnosis of congenital hypothyroidism. We suggest all newborns to be tested simultaneously for thyroid-stimulating hormone and thyroxine values at primary screening. A reevaluation of thyroid hormones after dopamine discontinuation is advisable in patients treated with dopamine.

[Indexed for MEDLINE]

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