Format

Send to

Choose Destination
J Appl Physiol (1985). 2006 Jul;101(1):60-7. Epub 2006 Mar 30.

Postnatal development of right atrial injection of capsaicin-induced apneic response in rats.

Author information

1
Pathophysiology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, New Mexico 87108, USA.

Abstract

Apnea and respiratory failure often occur in infants with pulmonary disease. Bronchopulmonary C-fiber (PCF)-mediated apnea is an important component of respiratory dysfunction. This study was undertaken to define the postnatal development of PCF-mediated apnea. The experiments were conducted in five groups of anesthetized, tracheotomized, and spontaneously breathing rats with ages at postnatal days P1-3, P7-9, P14-16, P21-23, and P56-58. Right atrial bolus injection of three doses of capsaicin (Cap), equivalent to 2, 4, and 8 microg/kg used previously in 450-g rats, was applied to stimulate PCFs. We found that 1) Cap-induced apneic response [percent change from the baseline expiratory duration (Te) values (deltaTe%)] and the sensitivity of this response (deltaTe%.microg(-1)) were significantly greater in the rats <P10 than those >P10; 2) the Cap-induced apneas were vagally dependent in all rats tested; and 3) bivagotomy-induced prolongation of Te was much greater in the rats <P10 than those >P10. From these findings we concluded that, compared with the older rats (>P10), the newborn rats have a stronger PCF-mediated respiratory inhibition that may contribute to infants' vulnerability to respiratory failure.

PMID:
16575027
DOI:
10.1152/japplphysiol.00085.2006
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center