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Biochem Biophys Res Commun. 2006 May 12;343(3):950-5. Epub 2006 Mar 20.

Identifying Hfq-binding small RNA targets in Escherichia coli.

Author information

1
Bioinformatics Laboratory and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

Abstract

The Hfq-binding small RNAs (sRNAs) have recently drawn much attention as regulators of translation in Escherichia coli. We attempt to identify the targets of this class of sRNAs in genome scale and gain further insight into the complexity of translational regulation induced by Hfq-binding sRNAs. Using a new alignment algorithm, most known negatively regulated targets of Hfq-binding sRNAs were identified. The results also show several interesting aspects of the regulatory function of Hfq-binding sRNAs.

PMID:
16574072
DOI:
10.1016/j.bbrc.2006.02.196
[Indexed for MEDLINE]

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