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BMC Med Genet. 2006 Mar 30;7:31.

The Glu27 genotypes of the beta2-adrenergic receptor are predictors for severe coronary artery disease.

Author information

1
Genetics Department, King Faisal Specialist Hospital and Research Centre (MBC - 03), P. O. Box 3354, Riyadh 11211, Saudi Arabia. kamero@kfshrc.edu.sa

Abstract

BACKGROUND:

The role of the Beta2-adrenoceptor (beta2-AR) Gln27Glu polymorphism in the manifestation of cardiovascular diseases is still unclear.

METHODS:

In the present study, we evaluated the potential relevance of the c.79 C>G (p.Gln27Glu) polymorphism of this receptor gene for coronary artery disease (CAD) and its associated risk factors in Saudi Arabs. Genotyping was performed by PCR using the confronting two-pair primer (PCR-CTPP) method.

RESULTS:

In the general population group (BD) (n = 895), 68.5% were homozygous wild-type C/C, 28.3% were heterozygous C/G and 3.2% were homozygous mutant G/G. Among the CAD patients (n = 773), 50.6% were homozygous wild-type C/C, 43.6% were heterozygous C/G and 5.8% were homozygous mutant G/G, while in the angiographed control group (CON) (n = 528), 71.8% were C/C, 24.4% C/G and 3.8% G/G genotypes. These results indicate that both the C/G (p = or < .001) and G/G (p = .005) genotypes are significantly associated with CAD, when compared to the CON group. In addition, C/G (p = or < .001) and G/G (p = or < .001) were significantly associated with CAD, when compared to the BD group. Furthermore, stepwise logistic regression showed that the genotype [C/G (p < .001) and G/G (p < .001)] increase the risk of CAD.

CONCLUSION:

These results shows that the Gln27Glu genotypes (homo- or heterozygous) of the beta2-AR may be independent predictors of severe CAD.

PMID:
16573811
PMCID:
PMC1481543
DOI:
10.1186/1471-2350-7-31
[Indexed for MEDLINE]
Free PMC Article
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