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Eur J Immunol. 2006 Apr;36(4):798-801.

Tolls for B cells.

Author information

1
Department for Humoral Immunology & Department for Immune Regulation, German Arthritis Research Centre, Berlin, Germany. fillatreau@drfz.de

Abstract

Priming of naive lymphocytes is important for yielding efficient immune responses. Mechanisms controlling this process are also important for preventing immune cells from attacking self-antigens. It is well known that signals provided by innate immune receptors, such as Toll-like receptors (TLR), are essential to induce dendritic cell maturation that subsequently allows the priming of naive T cells. In this issue of the European Journal of Immunology, it is shown that TLR stimulation effectively potentiates naive human B cell activation and production of antibodies in T-dependent immune responses. TLR signals can be delivered to B cells directly, or indirectly via cytokines provided by TLR-activated dendritic cells.

PMID:
16572389
DOI:
10.1002/eji.200636040
[Indexed for MEDLINE]
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