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Diabetologia. 2006 Jun;49(6):1169-74. Epub 2006 Mar 29.

Enhanced soluble CD40L in patients with the metabolic syndrome: Relationship with in vivo thrombin generation.

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1
IV Division of Internal Medicine, Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Viale del Policlinico, 00161 Rome, Italy.

Abstract

AIMS/HYPOTHESIS:

The metabolic syndrome is associated with proinflammatory and prothrombotic states. This study was designed to assess the behaviour of soluble CD40 ligand (sCD40L) and prothrombin fragment F (1+2), a marker of thrombin generation, in patients with the metabolic syndrome.

METHODS:

We investigated 106 patients with the metabolic syndrome, diagnosed according to the ATPIII report, and 104 subjects without the metabolic syndrome.

RESULTS:

Plasma values of sCD40L and F (1+2) were higher in patients with the metabolic syndrome (4.11+/-1.64 vs 2.61+/-0.89 ng/ml and 1.54+/-0.49 vs 0.87+/-0.21 nmol/l, respectively; p < 0.001) and were significantly correlated (r = 0.925, p < 0.001). Stepwise multiple linear regression analysis showed that sCD40L was significantly associated with F (1+2), female sex and waist circumference.

CONCLUSIONS/INTERPRETATION:

Patients with the metabolic syndrome have enhanced values of plasma sCD40L and F (1+2). The study provides further insight into the relationship between metabolic syndrome, inflammation and thrombosis.

PMID:
16570157
DOI:
10.1007/s00125-006-0222-7
[Indexed for MEDLINE]
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