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Am Heart J. 2006 Apr;151(4):878-81.

Single-nucleotide polymorphisms of VEGF gene are associated with risk of congenital valvuloseptal heart defects.

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1
Research Group for Paediatrics and Nephrology, Hungarian Academy of Sciences, Hungary.

Abstract

BACKGROUND:

Disturbed vascular endothelial growth factor (VEGF) production during early heart morphogenesis causes endocardial cushion malformation, which results in congenital heart disease (CHD). We tested whether functional VEGF -460T/C and +405G/C polymorphisms that have an impact on VEGF levels were associated with CHD.

METHODS:

Dried blood samples were collected from 102 CHD children and 112 healthy control neonates. Genotyping was done with polymerase chain reaction-restriction fragment length polymorphism (VEGF +405G/C) and real-time polymerase chain reaction methods (VEGF -460T/C).

RESULTS:

VEGF -460C allele frequency was similar in control and CHD subjects. VEGF +405C allele was less prevalent in controls than in CHD subjects (0.21 vs 0.42, P < .001). Having VEGF +405C presented increased risk for CHD (odds ratio [OR] 1.72, 95% CI 1.32-2.26). VEGF -460CT/+405CC allele associations did not occur in controls but in CHD patients (0% vs 13%, OR 2.26, 95% CI 1.93-2.64), whereas -460CT/+405GG allele association was more prevalent in controls (32% vs 16%, OR 0.58, 95% CI 0.37-0.89).

CONCLUSIONS:

VEGF gene and allele associations may be associated with increased risk of CHD.

PMID:
16569553
DOI:
10.1016/j.ahj.2005.10.012
[Indexed for MEDLINE]
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