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Antimicrob Agents Chemother. 1991 Aug;35(8):1647-50.

Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli.

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Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.


Thirteen spontaneous quinolone-resistant gyrB mutants of Escherichia coli KL16, including two that were examined previously, were divided into two types according to their quinolone resistance patterns. Type 1 mutants were resistant to all the quinolones tested, while type 2 mutants were resistant to acidic quinolones and were hypersusceptible to amphoteric quinolones. Nucleotide sequence analysis disclosed that all nine type 1 mutants had a point mutation from aspartic acid to asparagine at amino acid 426 and that all four type 2 mutants had a point mutation from lysine to glutamic acid at amino acid 447.

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