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Pediatr Infect Dis J. 2006 Apr;25(4):377-9.

Recurrent central nervous system blastomycosis in an immunocompetent child treated successfully with sequential liposomal amphotericin B and voriconazole.

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Division of Pediatric Hematology/Oncology, Children's National Medical Center, Washington, DC, USA.


Central nervous system involvement in infection with Blastomyces dermatitidis is uncommon, except in immunocompromised patients. We report a case of central nervous system blastomycosis occurring 18 months after treatment of pulmonary blastomycosis in an immunocompetent child. Our patient was successfully treated sequentially with liposomal amphotericin B followed by oral voriconazole without need for surgical resection.

[Indexed for MEDLINE]

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