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Circulation. 2006 Apr 11;113(14):1760-7. Epub 2006 Mar 27.

Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study.

Author information

1
Division of Nephrology, Department of Medicine, University of California, San Francisco, CA 94143-0532, USA. jix@medicine.ucsf.edu

Abstract

BACKGROUND:

Fetuin-A is a multifunctional hepatic secretory protein that inhibits the action of insulin in experimental animals. We evaluated the association between human serum fetuin-A and the metabolic syndrome (MetS) in a cohort of persons with coronary artery disease.

METHODS AND RESULTS:

We defined MetS by the National Cholesterol Education Program criteria among 711 nondiabetic outpatients with coronary artery disease. The mean age was 67 years, and 82% were male. We divided participants into quartiles by serum fetuin-A concentrations. A total of 45% of participants (80 of 177) in the highest quartile of fetuin-A had MetS compared with 24% of participants (42 of 177) in the lowest quartile (odds ratio, 2.7; 95% confidence interval, 1.7 to 4.2; P<0.001). This association persisted after adjustment for potential confounding variables, including hypertension, body mass index, and inflammatory biomarkers (adjusted odds ratio, 2.0; 95% confidence interval, 1.1 to 3.5; P=0.02). Higher fetuin-A quartiles were also strongly and independently associated with higher low-density lipoprotein, non-high-density lipoprotein (HDL), and triglyceride concentrations and lower HDL concentrations (all P<0.01).

CONCLUSIONS:

Higher human fetuin-A concentrations are strongly associated with MetS and an atherogenic lipid profile. Future studies should evaluate whether fetuin-A predicts coronary artery disease risk.

PMID:
16567568
PMCID:
PMC2776669
DOI:
10.1161/CIRCULATIONAHA.105.588723
[Indexed for MEDLINE]
Free PMC Article

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