Format

Send to

Choose Destination
See comment in PubMed Commons below
Mol Interv. 2006 Apr;6(2):89-97.

Iron dysregulation and neurodegeneration: the molecular connection.

Author information

1
Buck Institute for Age Research, Novato, California 94945, USA.

Abstract

Iron is essential for many biological processes however excess concentrations can be harmful to many tissues. Its amounts must therefore be carefully regulated in all cells of the body including those in the brain. Increased amounts of iron have been reported in many neurodegenerative disorders. Whether this increased iron contributes to neurodegeneration has been considered controversial. In this review, we discuss some recently identified anomalies in proteins linked with iron metabolism which signify a critical role for iron dysregulation in neurodegeneration.

PMID:
16565471
DOI:
10.1124/mi.6.2.6
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center