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Trends Genet. 2006 May;22(5):245-50. Epub 2006 Mar 27.

Elucidating cis- and trans-regulatory variation using genetical genomics.

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1
McGill University and Genome Quebec Innovation Centre, 740 Ave Dr. Penfield, Montreal, Quebec, Canada, H3A 1A4.

Abstract

Genetic variation, through its effects on gene regulatory networks, has an important role in determining biologic phenotypes and disease susceptibility. Recent studies using segregating populations have characterized variation in gene expression resulting from genetic differences and have used well-established assays to identify many cis-acting polymorphisms. Although trans effects have been shown to be globally important, their individual effects are small, such that their genome-wide identification remains a challenge. Two recent studies using approaches capitalizing on intercrossed mouse strains and novel computational methods have yielded examples of trans-regulatory networks.

PMID:
16564600
DOI:
10.1016/j.tig.2006.03.001
[Indexed for MEDLINE]
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