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Dev Biol. 2006 Jun 1;294(1):161-7. Epub 2006 Mar 29.

Sohlh1 is essential for spermatogonial differentiation.

Author information

1
Faculty Center, Department of Obstetrics and Gynecology, Baylor College of Medicine, 1709 Dryden Street, Suite 1100, Houston, TX 77030, USA.

Abstract

Spermatogonia are adult germline stem cells that can both self-renew and differentiate into spermatocytes. Little is known about factors necessary for spermatogonial differentiation. We identified a novel germ-cell-specific transcription factor that we named Sohlh1 (testis and ovary expressed basic helix-loop-helix (bHLH) transcription factor). In males, Sohlh1 is preferentially expressed in prespermatogonia and Type A spermatogonia. Loss of Sohlh1 causes infertility by disrupting spermatogonial differentiation into spermatocytes. Seven-day-old testes without Sohlh1 still express the testis-specific transcription factors Etv5, Taf4b, Zfp148, and Plzf, overexpress a novel Tohlh2 bHLH transcription factor, but lack LIM homeobox gene Lhx8 and show reduced expression of Ngn3. Sohlh1 represents the first testis-specific bHLH transcription factor that is essential for spermatogonial differentiation.

PMID:
16564520
DOI:
10.1016/j.ydbio.2006.02.027
[Indexed for MEDLINE]
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