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Cell. 2006 Mar 24;124(6):1111-5.

Stem cells and cancer: two faces of eve.

Author information

1
Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. mfclarke@stanford.edu

Abstract

Recent evidence suggests that a subset of cancer cells within some tumors, the so-called cancer stem cells, may drive the growth and metastasis of these tumors. Understanding the pathways that regulate proliferation, self-renewal, survival, and differentiation of malignant and normal stem cells may shed light on mechanisms that lead to cancer and suggest better modes of treatment.

PMID:
16564000
DOI:
10.1016/j.cell.2006.03.011
[Indexed for MEDLINE]
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