Format

Send to

Choose Destination
Curr Opin Pharmacol. 2006 Jun;6(3):244-50. Epub 2006 Mar 23.

Pulmonary and vascular pharmacology of sphingosine 1-phosphate.

Author information

1
Autoimmunity & Transplantation, Novartis Institutes for BioMedical Research, WSJ-386.101, Lichtstrasse 35, CH-4002 Basel, Switzerland. volker.brinkmann@novartis.com

Abstract

Dysregulation of vasomotor tone, endothelial barrier function and immune cell trafficking are central to the pathology of many lung diseases, including acute lung injury, adult respiratory distress syndrome, chronic obstructive pulmonary disease and asthma. There is increasing evidence that the serum sphingolipid sphingosine 1-phosphate and its G-protein-coupled receptors are pivotal not only in the regulation of lymphocyte migration, but also in the maintenance of vascular homeostasis and the preservation of permeability barriers that separate discrete compartments in the lung.

PMID:
16563863
DOI:
10.1016/j.coph.2005.12.004
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center