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Bioorg Med Chem Lett. 2006 Jun 1;16(11):2877-81. Epub 2006 Mar 24.

Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase.

Author information

1
The School of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, UK.

Abstract

An array of novel analogues of the marine oxylipins, the manzamenones and plakoridines, have been prepared in divergent fashion using an approach modelled on a biogenetic theory. Many of the target compounds show potent inhibition of DNA polymerases alpha and beta and human terminal deoxynucleotidyl transferase (TdT).

PMID:
16563761
DOI:
10.1016/j.bmcl.2006.03.005
[Indexed for MEDLINE]

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