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Int J Tuberc Lung Dis. 2006 Mar;10(3):310-6.

Comparison of mantoux skin test with three generations of a whole blood IFN-gamma assay for tuberculosis infection.

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South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.

Erratum in

  • Int J Tuberc Lung Dis. 2006 Jun;10(6):708.



A rural town in South Africa.


To compare the performance of Quanti-FERON assays with the tuberculin skin test (TST) for identifying latent tuberculosis infection (LTBI) in a high TB burden community.


In a cross-sectional study in healthy adults, we applied the TST and took blood for the three generations of QuantiFERON assays.


Of 358 participants whose results were analysed, 291 (81%) had a TST result of > or = 10 mm induration, and 187 (52%) > or = 15 mm. QuantiFERON-TB was positive in 215 (60%), QuantiFERON-TB Gold in 137 (38%), and QuantiFERON-TB Gold (In-Tube method) in 201 (56%). There was poor agreement between TST and QuantiFERON tests, and between the different generations of QuantiFERON tests (kappa = 0.12-0.50). Of the subset with TST indurations > or = 15 mm, 30-56% had negative QuantiFERON tests. However, positive Quanti-FERON tests were associated with males, who have a higher incidence of TB in this area.


We showed poor agreement between TST and the different QuantiFERON tests in diagnosing LTBI. The surprising discordance between the Quanti-FERON TB Gold and QuantiFERON TB Gold (In-Tube method) tests needs to be investigated further.

[Indexed for MEDLINE]

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