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Nat Rev Immunol. 2006 Apr;6(4):295-307.

Regulatory T cells, tumour immunity and immunotherapy.

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Department of Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-0346, USA.


Tumours express a range of antigens, including self-antigens. Regulatory T cells are crucial for maintaining T-cell tolerance to self-antigens. Regulatory T cells are thought to dampen T-cell immunity to tumour-associated antigens and to be the main obstacle tempering successful immunotherapy and active vaccination. In this Review, I consider the nature and characteristics of regulatory T cells in the tumour microenvironment and their potential multiple suppressive mechanisms. Strategies for therapeutic targeting of regulatory T cells and the effect of regulatory T cells on current immunotherapeutic and vaccine regimens are discussed.

[Indexed for MEDLINE]

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