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Future Oncol. 2005 Feb;1(1):67-78.

Role of IkappaB kinase in tumorigenesis.

Author information

1
Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. michu@mdanderson.org

Abstract

IkappaB kinase plays a central role in regulating NF-kappaB, is a key signaling molecule involved in controlling cell proliferation, survival, antiapoptosis, and tumorigenesis. Alternative pathways can also regulate NF-kappaB in an IkappaB kinase-independent manner. Emerging evidence indicates that IKK phosphorylates and inactivates forkhead box, class O (FOXO)-3a and promotes cell growth and tumorigenesis. Moreover, IKK and NF-kappaB play an important role in linking inflammation and tumorigenesis, and facilitate tumor maintenance and invasion. Thus, IKK and NF-kappaB are promising targets for drug discovery, and agents targeting the IKK/NF-kappaB and FOXO pathways may become therapeutic intervention for those patients with IKK/NF-kappaB-overexpressing cancers in the future.

PMID:
16555977
DOI:
10.1517/14796694.1.1.67
[Indexed for MEDLINE]

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