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Proc Biol Sci. 2006 Jan 22;273(1583):237-43.

Farm Scale Evaluations of spring-sown genetically modified herbicide-tolerant crops: a statistical assessment.

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  • 1Biomathematics and Bioinformatics Division, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.

Abstract

Primary results from the Farm Scale Evaluations (FSEs) of spring-sown genetically modified herbicide-tolerant crops were published in 2003. We provide a statistical assessment of the results for count data, addressing issues of sample size (n), efficiency, power, statistical significance, variability and model selection. Treatment effects were consistent between rare and abundant species. Coefficients of variation averaged 73% but varied widely. High variability in vegetation indicators was usually offset by large n and treatment effects, whilst invertebrate indicators often had smaller n and lower variability; overall, achieved power was broadly consistent across indicators. Inferences about treatment effects were robust to model misspecification, justifying the statistical model adopted. As expected, increases in n would improve detectability of effects whilst, for example, halving n would have resulted in a loss of significant results of about the same order. 40% of the 531 published analyses had greater than 80% power to detect a 1.5-fold effect; reducing n by one-third would most likely halve the number of analyses meeting this criterion. Overall, the data collected vindicated the initial statistical power analysis and the planned replication. The FSEs provide a valuable database of variability and estimates of power under various sample size scenarios to aid planning of more efficient future studies.

PMID:
16555793
PMCID:
PMC1560020
DOI:
10.1098/rspb.2005.3282
[PubMed - indexed for MEDLINE]
Free PMC Article
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