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Rhesus monkey brain imaging through intact skull with thermoacoustic tomography.

Author information

1
Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843-3120, USA.

Abstract

Two-dimensional microwave-induced thermoacoustic tomography (TAT) is applied to imaging the Rhesus monkey brain through the intact skull. To reduce the wavefront distortion caused by the skull, only the low-frequency components of the thermoacoustic signals (< 1 MHz) are used to reconstruct the TAT images. The methods of signal processing and image reconstruction are validated by imaging a lamb kidney. The resolution of the system is found to be 4 mm when we image a 1-month-old monkey head containing inserted needles. We also image the coronal and axial sections of a 7-month-old monkey head. Brain features that are 3 cm deep in the head are imaged clearly. Our results demonstrate that TAT has potential for use in portable, cost-effective imagers for pediatric brains.

PMID:
16555762
DOI:
10.1109/tuffc.2006.1610562
[Indexed for MEDLINE]

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