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Eur J Pharmacol. 1991 Apr 25;206(4):343-6.

Norepinephrine increases cyclic GMP in astrocytes by a mechanism dependent on nitric oxide synthesis.

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Instituto de Biología Fundamental V. Villar Palasi, Universidad Autónoma de Barcelona, Spain.


Norepinephrine induces a rapid and concentration-dependent rise (EC50 = 1.21 +/- 0.33 microM) in cyclic GMP levels in astrocyte-enriched cultures from rat brain. The response is partially mediated by alpha 1-adrenoceptors since a marked inhibition is observed in the presence of prazosin while the beta-antagonist propranolol shows a smaller effect and the alpha 2-antagonist yohimbine is ineffective. L-NG-methylarginine, an inhibitor of nitric oxide synthesis from L-arginine, blocks the norepinephrine-induced cyclic GMP accumulation. This effect is reversed by L-arginine.

[Indexed for MEDLINE]

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