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Eur J Pharmacol. 1991 May 17;197(2-3):157-60.

Excitatory action of some aspartate- and glutamate-containing dipeptides after intracerebroventricular injection in mice.

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Department of Pharmacology, Academy of Medical Sciences U.S.S.R., Leningrad.


The effects of some dipeptides, analogues of N-acetyl-alpha-L-aspartyl-L-glutamate, were studied after i.c.v. administration into mice in acute experiments. N-Acetyl-alpha-L-aspartyl-L-glutamate itself did not induce seizures in animals, but prevented glutamate-induced convulsions. All other dipeptides possessed excitatory glutamate-like actions. Some structural requirements for the excitatory effects of the dipeptides are discussed.

[Indexed for MEDLINE]

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