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Cell Cycle. 2006 Mar;5(5):512-8. Epub 2006 Mar 1.

Akt1 in endothelial cell and angiogenesis.

Author information

  • 1Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

Abstract

Akt, also known as Protein kinase B (PKB), regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Akt influences the expression and/or activity of various pro- and anti-angiogenic factors and Akt isoforms (Akt1, Akt2 and Akt3) have been proposed as therapeutic targets for angiogenesis-related anomalies such as cancer and ischemic injury.

PMID:
16552185
PMCID:
PMC1569947
DOI:
10.4161/cc.5.5.2538
[PubMed - indexed for MEDLINE]
Free PMC Article
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