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Clin Nucl Med. 2006 Apr;31(4):213-4.

Positron emission tomography in well differentiated fetal adenocarcinoma of the lung.

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Department of Surgery, Department of Veterans Affairs Medical Center, Dayton, OH 45428, USA.


A 47-year-old woman with a 20 pack-year history of cigarette smoking presented with a chest x-ray demonstrating a left upper lobe lung density. Computed tomography of the chest showed a 3-cm lobulated mass in the apical left upper lobe. The lesion demonstrated intense focal uptake on FDG-PET scanning. The patient underwent left upper lobectomy. Pathology demonstrated the histologic and immunohistochemical findings of a well differentiated fetal adenocarcinoma (WDFA). The intense FDG-PET uptake and abundant glycogen stores associated with WDFA may be the result of its embryonic derivation and differential expression of glucose transporter proteins.

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