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Parkinsonism Relat Disord. 2006 May;12(4):205-10. Epub 2006 Mar 23.

Stimulation of the subthalamic nucleus in Parkinson's disease: cognitive and affective changes are not linked to the motor outcome.

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Neurology and Movement Disorders Unit, EA2683, University of Lille 2 and Lille University Hospital, Lille, France.



Subthalamic nucleus deep brain stimulation (STN0 DBS) is a widely performed surgical treatment in PD. However, the relationship between motor results and cognitive/behavioural modifications is unclear.


This study investigated the correlation patterns of the motor, cognitive and behavioural consequences of STN DBS with respect to positioning of the active contact.


Fifty-eight consecutive PD patients having undergone STN DBS were assessed pre-operatively and 12 months after surgery.


Motor, cognitive and behavioural results were neither correlated to each other nor linked to the position of the active contact. Three patients with a history of pre-operative, dopaminergic psychosis or post-surgical confusion became demented. Age and a distant history of depression were associated with the occurrence of post-surgical depression.


Correct screening of patients for STN DBS remains an important issue, since the current implantation procedure is not able to take account of potential functional heterogeneity within the target.

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