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Parkinsonism Relat Disord. 2006 May;12(4):205-10. Epub 2006 Mar 23.

Stimulation of the subthalamic nucleus in Parkinson's disease: cognitive and affective changes are not linked to the motor outcome.

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1
Neurology and Movement Disorders Unit, EA2683, University of Lille 2 and Lille University Hospital, Lille, France. mp-perriol@chru-lille.fr

Abstract

BACKGROUND:

Subthalamic nucleus deep brain stimulation (STN0 DBS) is a widely performed surgical treatment in PD. However, the relationship between motor results and cognitive/behavioural modifications is unclear.

OBJECTIVE:

This study investigated the correlation patterns of the motor, cognitive and behavioural consequences of STN DBS with respect to positioning of the active contact.

METHODS:

Fifty-eight consecutive PD patients having undergone STN DBS were assessed pre-operatively and 12 months after surgery.

RESULTS:

Motor, cognitive and behavioural results were neither correlated to each other nor linked to the position of the active contact. Three patients with a history of pre-operative, dopaminergic psychosis or post-surgical confusion became demented. Age and a distant history of depression were associated with the occurrence of post-surgical depression.

CONCLUSION:

Correct screening of patients for STN DBS remains an important issue, since the current implantation procedure is not able to take account of potential functional heterogeneity within the target.

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