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Physiol Behav. 2006 May 30;87(5):903-10. Epub 2006 Mar 20.

Effect of gastric distension prior to eating on food intake and feelings of satiety in humans.

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Clinical Research Center, Department of Research, University Hospital, CH-4031 Basel, Switzerland.


The factors that regulate food intake and satiation are complex; it has been suggested that signals arising from the small intestine and the stomach play an important role. It is still unknown, to what extent pure mechanical distension of the gastric fundus and antrum can alter food intake. Our aim was therefore to investigate whether transient gastric fundus and antrum distension applied prior to meal ingestion can trigger satiation in healthy humans. Two sequential, randomized, double-blind, four-period cross-over designed studies were performed in 24 healthy male volunteers: (1) 12 subjects underwent four intragastric balloon distension experiments of the fundus (0, 400, 600, 800 ml) before a standard meal intake; (2) 12 subjects underwent intragastric balloon distension experiments of the antrum under the following conditions: 0 ml balloon distension of the antrum plus intraduodenal (ID) saline or ID fat, and 300 ml antrum distension plus ID saline or ID fat. Shortly after the distension period, subjects were free to eat and drink as much as they wished. Neither gastric fundus nor antrum distension showed a reduction in calorie intake. Distending the fundus affected the mean Visual Analogue Scale (VAS) in the premeal period: subjects experienced a reduced degree of hunger and a concomitant feeling of fullness, but the effect was only apparent during distension with a volume of 600 ml or even 800 ml. Cholecystokinin (CCK) and peptide YY (PYY) were not altered by gastric distension. Transient pure mechanical distension of the fundus or the antrum prior to a meal does not trigger satiation.

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