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Eur J Cell Biol. 2006 Apr;85(3-4):255-63. Epub 2005 Oct 10.

Integrin-linked kinase and its partners: a modular platform regulating cell-matrix adhesion dynamics and cytoskeletal organization.

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1
Institute of Signaling, Developmental Biology and Cancer Research, CNRS-UMR6543, Centre Antoine Lacassagne, 33 Avenue de Valombrose, F-06189 Nice, France.

Abstract

Integrin-linked kinase (ILK) represents a key component of integrin signaling complexes that functions in concert with multiple binding partners to transmit cues from the extracellular matrix environment to the actin cytoskeleton. Both gain- and loss-of-function approaches to study ILK have confirmed the essential role of this protein in regulating cell-matrix adhesion dynamics and cytoskeletal organization.

PMID:
16546570
DOI:
10.1016/j.ejcb.2005.09.002
[Indexed for MEDLINE]
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