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Biochim Biophys Acta. 2006 Aug;1766(1):79-87. Epub 2006 Mar 3.

The Ets transcription factors of the PEA3 group: transcriptional regulators in metastasis.

Author information

1
UMR 8161, Institut de Biologie de Lille, CNRS/Université de Lille I/Université de Lille II/Institut Pasteur de Lille, BP 447, 1 rue Calmette, 59021 Lille Cedex, France. yvan.delaunoit@ibl.fr

Abstract

The PEA3 group is composed of three highly conserved Ets transcription factors: Erm, Er81, and Pea3. These proteins regulate transcription of multiple genes, and their transactivating potential is affected by post-translational modifications. Among their target genes are several matrix metalloproteases (MMPs), which are enzymes degrading the extracellular matrix during normal remodelling events and cancer metastasis. In fact, PEA3-group genes are often over-expressed in different types of cancers that also over-express these MMPs and display a disseminating phenotype. Experimental regulation of the synthesis of PEA3 group members influences the metastatic process. This suggests that these factors play a key role in metastasis.

PMID:
16546322
DOI:
10.1016/j.bbcan.2006.02.002
[Indexed for MEDLINE]

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