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J Ind Microbiol Biotechnol. 2006 Jul;33(7):523-31. Epub 2006 Mar 17.

Drug discovery from natural products.

Author information

1
Cetek Corporation, 260 Cedar Hill Street, Marlborough, MA 01752, USA. v.gullo@cetek.com

Abstract

Natural product compounds are the source of numerous therapeutic agents. Recent progress to discover drugs from natural product sources has resulted in compounds that are being developed to treat cancer, resistant bacteria and viruses and immunosuppressive disorders. Many of these compounds were discovered by applying recent advances in understanding the genetics of secondary metabolism in actinomycetes, exploring the marine environment and applying new screening technologies. In many instances, the discovery of a novel natural product serves as a tool to better understand targets and pathways in the disease process. This review describes recent progress in drug discovery from natural sources including several examples of compounds that inhibit novel drug targets.

PMID:
16544162
DOI:
10.1007/s10295-006-0107-2
[Indexed for MEDLINE]

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