Format

Send to

Choose Destination
See comment in PubMed Commons below
Arq Bras Endocrinol Metabol. 2005 Dec;49(6):959-63. Epub 2006 Mar 16.

[Magnesium deficiency and insulin resistance in patients with type 2 diabetes mellitus].

[Article in Portuguese]

Author information

1
Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA. mlourdeslima@hotmail.com

Abstract

Magnesium is a predominantly intracellular ion, and it is a cofactor in more than 300 enzymatic reactions, like tyrosinokinase activity. Its deficiency may increase insulin resistance, especially in patients with metabolic syndrome or type 2 diabetes. This study evaluated in 27 patients with poorly controlled type 2 diabetes if there was correlation between intracellular magnesium levels, laboratorial indexes of insulin resistance and glycemic control. Decreased serum and intracellular magnesium depletion were found in 75% and 30.8% of patients, respectively. A negative correlation between intracellular magnesium levels (ICMg) and BMI and HbA1 was found. The homeostasis model assessment for insulin resistance (HOMA-IR) was higher than 3.0 in 59.2% of patients and there was a tendency to negative correlation with ICMg levels, although without statistical significance. Despite the small number of patients, this study shows that magnesium deficiency is frequent in patients with diabetes and its correlation with insulin resistance should be more studied.

PMID:
16544020
DOI:
/S0004-27302005000600016
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Scientific Electronic Library Online
    Loading ...
    Support Center