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Mol Cell. 2006 Mar 17;21(6):732-4.

The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer.

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1
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom.

Abstract

Low levels of Nrf2 activity predispose cells to chemical carcinogenesis. Surprisingly, Padmanabhan et al. (2006) provide evidence in a recent issue of Molecular Cell to support the notion that elevated Nrf2 activity may also play a role in the evolution of cancer.

PMID:
16543142
DOI:
10.1016/j.molcel.2006.03.004
[Indexed for MEDLINE]
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