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Mol Cell. 2006 Mar 17;21(6):727-8.

Chemical ligation--an unusual paradigm in protease inhibition.

Author information

1
Department for Haemostasis Biochemistry, Biopharmaceuticals Research Unit, Novo Nordisk, Novo Nordisk Park, DK-2760 Måløv, Denmark.

Abstract

Some protease inhibitors use uncommon mechanisms to restrain the activity of their target enzymes. A recent paper in Chemistry and Biology (Lu et al., 2006) demonstrates a curious mechanism of inhibition of a caspase, relying on principles of native peptide ligation.

PMID:
16543139
DOI:
10.1016/j.molcel.2006.03.001
[Indexed for MEDLINE]
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